Tuesday, February 26, 2013

FDA expands approval of Bayer cancer drug

WASHINGTON (AP) -- The Food and Drug Administration on Monday expanded approval of a Bayer cancer pill to treat tumors of the intestinal tract that don't respond to other treatments.

The drug is called Stivarga and regulators approved it to treat gastrointestinal stromal tumors that cannot be surgically removed and no longer respond to other FDA-approved drugs.

The FDA previously approved Stivarga to treat colorectal cancer. It works by blocking several enzymes that promote cancer growth.

The FDA approved the drug for the new use based on a study of nearly 200 patients who were randomly assigned to take Stivarga or a placebo pill.

Patients taking the drug experienced a nearly four month delay in the growth of their tumors compared to taking placebo.

Serious side effects of Stivarga in clinical trials included liver damage, severe bleeding, blistering and peeling of skin, high blood pressure, heart attacks and perforations.

Other drugs approved to treat intestinal tumors include Gleevec, from Novartis, and Sutent, made by Pfizer Inc.

Bayer HealthCare is a subsidiary of Germany's Bayer AG

Source: http://news.yahoo.com/fda-expands-approval-bayer-cancer-195130061.html

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Guys on Girls, Season 2

girls_jessa_2_7

Photo by Jessica Miglio/HBO

Jemima Kirke.

David Haglund: Bryan, the last time you and I discussed Girls, after this season?s coke-fueled third episode, you seemed to be coming around to the show?despite your problems with its principal protagonist, Hannah (Lena Dunham). You hoped that she would become more ?self-aware? as the season progressed. Arguably, we saw that happen, at least a little bit, in ?Video Games,? tonight?s episode, though it mostly focused on Jessa (Jemima Kirke). What did you think?

Bryan Lowder: I?ve really come around to the show this season?not necessarily as an avid fan, but as a regular viewer who appreciates the general thrust of the series. And you?re right: This episode absolutely brought a needed dose of reality to Hannah, and I enjoyed watching her deal with it?she even had to walk to the Metro North station all by herself. You forget how much a city like?New York can provide the infrastructure necessary to support a whole class of helpless, un-self-aware narcissists. A trip upstate, to a place where there are no subways that will whisk you home at 5 a.m. can?like a strange, attractive man waiting on the next block to put you up for the weekend?inspire a little reflection on your circumstances.

Haglund: As can a strange, less attractive man?perhaps boy is a more accurate descriptor?whose mother is married to the English father of your eccentric friend. I thought of Hannah?s impulsive, assertive kiss of Joshua (Patrick Wilson) when Frank made a similarly optimistic pass at a more experienced and sophisticated visitor. I wonder if that was a deliberate echo. In any case, the consequences of Frank?s daring seemed much less pleasant (and far more brief) than what Hannah managed with an older paramour a couple episodes ago. Before we get to that eccentric friend, any ideas why Hannah?s urinary tract infection was so prominently featured in this episode? More wisdom through suffering? Or was the point that some pain comes with no reward? Or maybe there was nothing to be gleaned from that at all?

Lowder:?Aww, you had to bring up to the UTI, didn?t you? I?ll get to that in a sec, but first, let me reply to your astute observation about Frank. On a basic level, that plot-line looked at what happens when a bunch of youngish people get together in a cabin-in-the-woods scenario?specifically, situational lust that may or may not be regrettable. More importantly, the encounter forced Hannah to recognize that her experience-seeking actually has consequences for other people. I?m thinking of the scene post-coitus, when Frank says Hannah used him and hints at some kind of sexual confusion with regard to his golden-boy friend, Tyler. Heretofore, Hannah?s sexcapades have been treated as occasionally grotesque and intermittently funny divertissements in which everyone goes back to their apartments in the morning. Here was a young man who really did feel used, and emotionally wounded, even if he initiated the encounter. Couldn?t she tell there was some energy between those two boys? I could.

As for the UTI, I think it was brought in mostly so we could see Hannah peeing by the tracks and making that weird cat sound. But maybe it, too, was meant to hint at the consequences of sex?with Sandy, with Joshua, with whoever punched her in the chest and then came in that spot?

Haglund:?But I thought the Joshua interlude was a fantasy! Actually, I didn?t. And perhaps it was an imaginary sexcapade with real toads in it, so to speak. Or maybe the UTI was just there to highlight Jessa?s hippie inclinations and dubious worldiness?apparently that garlic-clove folk-remedy is really intended for yeast infections.

You know, I feel even more out of my depth discussing this show than usual.?Anyway, you?re exactly right about Frank. For once, Hannah was unquestionably the one being careless about another person?s feelings vis ? vis a sexual encounter. It definitely had a Cabin in the Woods feel: That cemetery setting was no accident, surely?and that ?look ma, no eyes? driving sequence was precisely the sort of thing teenagers do in horror movies before one of them gets brutally murdered.

But let?s talk about Frank?s mom (Rosanna Arquette!)?and stepdad (Ben Mendelsohn). Is he the sort of father you imagined Jessa might have? Does this bit of backstory make her a more interesting, complicated character for you? And do you agree with me that Jemima Kirke pulled off crying on cue better than her castmates, Dunham (who had to do it two episodes ago) and Allison Williams (who did it last week)?

Lowder: You know, now that I think about it, I guess I imagined Jessa would have a colder father, a high-powered businessman or whatnot against whom she might be rebelling. Then again, I guess this dad is cold in his own, hippie-dippie and undependable way. I?m hesitant to let ?daddy issues? explain all of Jessa?s problems, but maybe we?re not meant to take this episode so simply. Remember, dad did remind Jessa that she herself has not shown up for the past six ?occasions??clearly, both people have a problem with follow-through. As for whether it made her more interesting? I guess it made me sad for her more than anything. It made me pity her for how that lack of peace must feel. And I?m guessing that was the point, given Hannah?s call to her parents later. Hannah told them she felt like she had a safety net under her, even though they don?t get along and are all ridiculous in their own ways. Putting such drama aside, there is a core stability there that is a privilege indeed.

Haglund:?Well put, Bryan. Hannah?s description of that feeling?that it?s like ?there?s a hammock under the earth protecting me??was similarly eloquent, and emphasized, consciously or no, the privilege of having such supportive (financially and otherwise) parents. All the dad stuff reminded me of last week, when Ray said he felt like Shoshanna?s father, and Adam called them ?babies holding hands.? In ?Video Games,? Jessa says, ?I?m the child, I?m the child,? while sobbing on a swing?and this after telling Hannah to ?grow up,? just as Marnie did earlier this season. Seems like maybe the show is trying to point out that we don?t ever totally grow up; we just get older, and while we may mature in some ways, our childishness doesn?t ever entirely go away. Or maybe I?m just speaking for myself here.

Speaking of childish things, why do you think the title for this episode was taken from that bizarre ?video games? rant that Petula went off on? That was another bit of thematic oddness I couldn?t quite square.

Lowder:?Well, Petula may be the most childish of them all. Her mother-earth, rabbit-eating, ?seminar?-going schtick was completely insufferable, and suggested a total disconnect from reality. Which is fine, I guess, since she lives in a video game. I?m not sure exactly why (or if) that rant was so thematically important?but I suppose the characters in this episode were in a strange place with unfamiliar challenges? (Like peeing outside, for instance.) And this might be a stretch, but perhaps the notion of a safety net also comes in here: Because of her parent?s stability and support, Hannah could fail and still have a second ?life,? whereas Jessa might not.

Haglund:?Interesting. That?s more than I came up with. (Also: Who would drive with their eyes covered except someone who thought they got an extra life?) Maybe our commenters will have some other suggestions. And perhaps our one-time conversation partner Bruce Eric Kaplan?the second man in a row to get sole writing credit for an episode of Girls?just liked the sound of the phrase. Or was thinking of the Lana Del Rey song?

Speaking of pop songs, I thought the music, one of the real strengths of this show, was particularly good tonight. I have a soft spot for Aimee Mann?whose husband, by the way, scores the series (more ?nepotism?!)?and her ?How Am I Different?? was perfect here, echoing Jessa?s dad?s comments that they?re ?not like other people,? a claim that ?Video Games? both proves and disproves: The Johansson clan is a little weird, to be sure, but deep down, most of our needs are pretty similar. Also, the lines ?Because this show is/ Too well designed/ Too well to be held with only me in mind? are (coincidentally, I assume) a remarkably apt bit of commentary on Season 2 of Girls.

Anything else you particularly liked?or didn?t like?about this episode (besides, of course, Hannah?s comment that old computers ?look like doghouses?)?

Lowder:?I really liked how well the episode caught the experience of being a stranger in a family home. Petula called Hannah the ?cushion,? and that immediately rang true, having gone home with friends and boyfriends to domestic spaces that were sometimes in need of them. And I didn?t really dislike anything this time around?other than the dangerous driving. Definitely hated that.

Source: http://feeds.slate.com/click.phdo?i=c980ba4068ddc7a57ff1535ace09569d

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Monday, February 25, 2013

Legal immigration needs to be easier | WE Blog | Wichita Eagle Blogs

U.S. Rep. Mike Pompeo (in photo), R-Wichita, identified one of the big problems that need to be fixed as part of federal immigration reform: The current legal immigration system is so backlogged and broken that it encourages illegal immigration. ?Our immigration policy is completely backward,? Pompeo told the Topeka Capital-Journal. ?Today, if you want to come here in a legal way, with proper paperwork, it is very difficult. If you want to come here unlawfully, it?s easier.?

Source: http://blogs.kansas.com/weblog/2013/02/legal-immigration-needs-to-be-easier/

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South Dakota legislator calls MMA ?Child porn of sports,? while governor says it?s too violent

A bill to create an athletic commission in South Dakota is going nowhere fast, largely thanks to the ignorance of Gov. Dennis Daugaard and state house Rep. Steve Hickey.

Their primary objective is to ban sanctioned mixed martial arts in the state. In a blog post, Hickey writes that, "MMA Cage Fighting is the child porn of sports."

The lack of knowledge and the lack of research both Daugaard and Hickey showed about MMA has to be frightening for persons who live in South Dakota. If they can't be bothered to do the minimal research required to learn that MMA is far safer than other "mainstream" sports, including football, it's scary to think about the laws they'll pass in the state regarding education, health care and budgets.

The UFC is the largest MMA promoter in the world. No fighter has ever suffered traumatic brain injury, let alone died, in the UFC's 20-year history. A 2006 study done by researchers at Johns Hopkins University and which appeared in the Journal of Sports Science and Medicine found MMA has far less traumatic brain injury than other sports.

Mixed Martial Arts competitions have changed dramatically since the first Ultimate Fighting Championship in 1993. The overall injury rate in MMA competitions is now similar to other combat sports, including boxing. Knockout rates are lower in MMA competitions than in boxing. This suggests a reduced risk of TBI [traumatic brain injury] in MMA competitions when compared to other events involving striking.

MMA events must continue to be properly supervised by trained referees and ringside physicians, and the rules implemented by state sanctioning?including weight classes, limited rounds per match, proper safety gear, and banning of the most devastating attacks? must be strictly enforced. Further research is necessary to continue to improve safety in this developing new sport.

A 2008 study released by the British Journal of Sports Medicine reached the same conclusions. After a five-year study, its authors wrote:

Injury rates in regulated professional MMA competition are similar to other combat sports; the overall risk of critical sports-related injury appears low. Additional study is warranted to achieve a better understanding of injury trends and ways to further lower injury risk in MMA.

The simple fact is that a random NFL player is at far greater risk of a serious brain injury than is a random MMA fighter. Sadly, neither Gov. Daugaard nor Rep. Hickey bothered to do much investigation or educate themselves before speaking out.

South Dakota state house Rep. Mark Johnston introduced a bill to create an athletic commission in the state for the express purpose of making the sport safer. According to the Argus Leader, Johnston said his goal is to prevent unregulated events where tragedies could possibly occur.

A state athletic commission's job is, at the core, to protect the fighters. It makes sure the proposed matches are fair and that promoters have doctors and an ambulance at all events. The commissions also require qualified referees, who stop fights when one fighter is in danger. It also requires fighters to undergo extensive medical examinations before fighting to make certain they are fit to compete. States such as Nevada, California and New York, with strong commissions, have discovered injuries fighters didn't know they had and prevented them from competing. That wouldn't be the case in South Dakota, with no commission to require those tests.

A fear of many states with strong commissions is that promoters will travel across state lines to put on shows in states such as South Dakota, where there is no regulation and where, as a result, costs are less. But the result is that it is far less safe for the competitors.

Sadly, neither Daugaard nor Hickey recognize that. Hickey told the Argus Leader he was angered by the thought of his state sanctioning MMA.

I'm offended that the state would legitimize cage-fighting and the bloody violence that those kinds of spectacles create. I think it's interesting that we declare that it is a crime for one human being to strike another, and yet the state now proceeds to legitimize, and label a sport, cage-fighting.

With all due respect, Gov. Daugaard, a few points:

? It is a crime for one human to strike another outside of the bounds of athletic competition. But it is no crime to strike another in the context of sport and when doctors and referees are available to protect the athletes and where the athletes have signed a contract to compete against each other.

? MMA fights sometimes get bloody. But no fighter to my knowledge has ever suffered anything worse than scarring as a result of being cut. It is important to note that a lot of the cuts are on the forehead above the eyes, where they mix with sweat and make them seem far worse than they are.

? States that have athletic commissions ban fighters who have sustained head injuries from competing again for several months. And before even being allowed to practice in a gym, the fighter needs to be cleared by a doctor.

? MMA is a combination of sports, many of which are already legal in South Dakota, including boxing, wrestling, karate, jiu-jitsu and judo.

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Source: http://forums.ferra.ru/index.php?showtopic=54651

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Kristen Stewart Oscars Fashion: Grade It!

Source: http://www.thehollywoodgossip.com/2013/02/kristen-stewart-oscars-fashion-grade-it/

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'Sequester' on president's agenda at meeting with governors

President Barack Obama on Monday is expected to implore the nation's governors to put pressure on Congress to avoid the sequester as Obama speaks to the nation's governors at the White House.

Members of the Obama administration, heads of federal agencies and others have been issuing severe warnings to Congress regarding the sequester-- $85 billion in across-the-board spending cuts that will go into effect March 1 absent a budget. Warnings have been released threatening fewer responders to handle wildfires, reduced food safety inspection, less help for vulnerable Americans and on Friday, widespread flight delays and cancellations.

"Travelers should expect delays. Flights to major cities like New York, Chicago, San Francisco and others could experience delays up to 90 minutes during peak hours, because we have fewer controllers on staff. Delays in these major airports will ripple across the country," Transportation Secretary Ray LaHood told reporters at Friday's White House press briefing after announcing that the Federal Aviation Administration (FAA) plans massive furloughs and closing air traffic control towers if the sequester goes into effect.

The White House on Sunday night released state-by-state reports detailing what they say would be "devastating" impacts on each state as a result of the sequester, but the?topic of the sequester was notably absent from Obama's speech Sunday night to the governors, who are in town for the National Governors Association's (NGA) annual winter meeting.

Instead, the president at the White House dinner struck an appreciative tone, commending the governors for steering their states through tough times.

Democratic Gov. Jack Markell of Delaware, chair of the NGA, followed Obama's address Sunday night by emphasizing the absence of politics from the night's celebration. "On this one night it?s a relief -- politics doesn?t drive the conversation. We don?t speak of partisan issues or presidential aspirations," Markell said.

But Markell did note the sequester.

"One thing for sure is certain -- you don?t let issues fester.? You get to deal with education and health care, and even the sequester," Markell said to laughter and applause from the audience.

Republicans such as Speaker John Boehner have publicly stated their opposition to the sequester, though others have threatened they are willing to let it go into effect.

Some Republicans over the weekend continued to accuse the administration of exaggerating the sequester's impact.

"They have plenty of flexibility in terms of discretion on how they spend money. There are easy ways to cut this money that the American people will never feel," Republican Sen. Tom Coburn of Oklahoma said on Fox News Sunday.

The president is slated to address the governors at 11:05 a.m. ET from the White House State Dining Room. Vice President Joe Biden, First Lady Michelle Obama and Second Lady Dr. Jill Biden are also scheduled to speak.

Source: http://news.yahoo.com/blogs/ticket/obama-expected-address-sequester-monday-meeting-governors-143539950--politics.html

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