Source: http://the-gadgeteer.com/2013/04/24/this-gives-crank-telephones-a-whole-new-meaning/
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Wednesday, April 24, 2013
This gives ?crank telephones? a whole new meaning?
Did you ever see one of those old, wall-mounted telephones that you had to crank to get the operator’s attention in old movies? ?Well, the Crankerator isn’t like that. ?This accessory from Photojojo is a backup battery with an emergency power source. ?It works with smart phones, cameras, and tablets, and a fully charged Crankerator [...]
Plantronics BackBeat GO stereo Bluetooth headphones review
Back at PAX East I met up with the guys at Plantronics, and they gave me a set of light and sporty Backbeat GO stereo Bluetooth headphones to try out. They adopt the ultra-light look that seems to be all the rage in stereo Bluetooth accessories. As if the form factor wasn't enough to entice music-loving busybodies, the Plantronics Bluetooth guy told me that there's a light oleophobic coating on the headphones to fend off sweat.
In terms of sheer looks, the Backbeat GO headphones are very classy. They're available in black and white, the thin tangle-free wire connecting each bud has a nice matte finish, and the two-tone look is very catching. Both buds have swappable gels (small, medium, and large are included) and clear rubber stabilizing braces, but most of the functional stuff is on the right side. There you'll find the in-line mic with power and media controls and the micro USB charging plug tucked behind a flap in the earbud. The front of the earbud also has an LED indicator, so folks know you aren't just a crazy person talking to yourself when taking a call. On the software side, battery life shows up as a separate indicator on iOS devices when paired.
Operation is pretty standard and what you'd expect. Holding up and down on the volume keys skips tracks, holding down the raised play button initiates Siri. Pairing mode is initiated by holding down the power button extra long when turning it on. Call control includes taking calls, hanging up, putting calls on hold, and redialing - provided you can remember which one is a two-second press which is a double-press of the play button.You get audio notifications when the Backbeat GO is turned on, makes a connection, and is running low on batteries. Listed battery life is around 4 hours, which lines up with my experience.
Now, I tend to be really picky about my in-ear headphones. The Bose in-ear headphones I (and Android Central's Phil Nickinson) use regularly are insanely comfortable, and I've yet to find anything better. You can seriously wear those things day-in and day-out without a problem, and they sound fantastic, buuuuuut you've gotta deal with a wire. That said, even with the smallest earbuds, I found it hard to wear the Backbeat GO headset for longer stretches. Though the old Backbeat 903 headphones didn't sit as closely in the ear canal as the Backbeat GO headset and the earpieces were a fair bit bigger, I found them generally more comfortable. On top of comfort, you've got to deal with the usual issue of in-ear headsets: earwax occasionally gunking up the gel. Insofar as portability and ease of use, the Backbeat GO headphones earn high marks. The cable has been specifically designed to be tangle-free, and I've yet to have any issues on that front.
As for sound quality, the Backbeat GO is on the tinny side. For phone calls and podcasts, that's okay, but I've found busy, bass-heavy music doesn't come through particularly well. On the upside, the earbuds are snug enough that there's ample noise cancellation.
The good
- Stylish design
- Lightweight and portable
The bad
- Uncomfortable earbuds
- Tinny audio
The bottom line
The Plantronics Backbeat GO headphones are perfect for anyone looking for music that won't get in the way of their workout. There's enough battery life to get you through a lengthy run or bike ride, and it's very easy to store. Your m,ileage may vary for comfort, and the audio quality is distinctly tinny, which may grate on audiophiles looking for deep, true sound.
- $119.99 (now on sale for $99.99) - Buy now
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Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/e1X7My9EPVM/story01.htm
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Stocks open little changed on mixed earnings news
NEW YORK (AP) ? Stock indexes are little changed in early trading on Wall Street following mixed earnings results from Apple, Ford, Boeing and other major U.S. companies.
The Dow Jones industrial average and the Standard & Poor's 500 index were moving between small gains and losses shortly after the opening bell Wednesday.
As of 9:45 a.m. Eastern the Dow was down seven points at 14,715 and the S&P 500 was up two points at 1,580.
The Nasdaq composite was up four points at 3,273.
Earnings will continue to roll out this week.
Online game maker Zynga reports after the closing bell. For the remainder of the week, earnings are expected from Dow Chemical, Southwest Airlines, UPS, Exxon Mobil and Burger King.
Source: http://news.yahoo.com/stocks-open-little-changed-mixed-earnings-news-135022820--finance.html
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Sony HX50V: A Massive Superzoom Camera Dressed Like a Skinny Superstar
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Tuesday, April 23, 2013
Sharon Osbourne says she's not divorcing Ozzy
NEW YORK (AP) ? Sharon Osbourne says she and husband Ozzy aren't splitting.
Osbourne addressed recent rumors of their family problems on Tuesday's edition of "The Talk," the CBS chat show she co-hosts.
She told viewers she had not been aware of her husband's year-and-a-half-long relapse into prescription drug and alcohol abuse, which he made public in an apologetic Facebook post last week.
She says she is "devastated" by their struggles, but she added that the couple has dealt with worse before.
The TV personality and music manager blinked back tears as she said, "This, too, shall pass."
Ozzy Osbourne was a founding member of heavy-metal pioneers Black Sabbath, but he left the group in 1979. The 64-year-old has since rejoined, and the band's new studio album is out in June.
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Genetics defines a distinct liver disease
Monday, April 22, 2013
Researchers have newly associated nine genetic regions with a rare autoimmune disease of the liver known as primary sclerosing cholangitis (PSC). This brings the total number of genetic regions associated with the disease to 16.
Approximately 70 per cent of people who suffer from PSC also suffer from IBD. The team showed that only half of the newly associated genetic regions were shared with inflammatory bowel disease (IBD). For the first time, this definitively proves that PSC, although genetically related to IBD, is a distinct disease.
PSC is a chronic, progressive disease of the bile ducts that channels bile from the liver into the intestines. It can cause inflammation of the bile ducts (cholangitis) and liver scarring that leads to liver cirrhosis and liver failure. There are no effective treatments available. Although PSC affects only one in 10,000 people, it is a leading cause of liver transplant surgery.
"Before our study, it was never quite clear whether PSC was a complication of IBD or a distinct disease in its own right," says Dr Carl Anderson, lead author from the Wellcome Trust Sanger Institute. "We have proven it to be a unique disease, and hope that our results will inform the development of more effective treatments, designed to target the biological pathways involved in causing the disease".
The work involved an international group of scientists from the International PSC study group recruiting patients from 13 countries within Europe and North America. Without this large collaborative effort it would not have been possible to obtain the large number of patient DNA samples necessary for the study.
The team used DNA genotyping technology to survey more thoroughly regions of the genome known to underlie other immune-related diseases to discover if they also play a role in PSC susceptibility.
In addition to the nine genetic regions newly associated, they also saw strong signals at three regions of the genome previously associated with the disease. Of these twelve genetic regions, six are also associated with IBD, while the six other regions showed little to no association in a recent large study of IBD.
"Using the Immunochip genotyping chip, we can pull apart the genetic relationships between these autoimmune diseases and begin to see not only their genetic similarities, but also the differences," says Jimmy Liu, PhD student and first author from the Wellcome Trust Sanger Institute. "As PSC is a rare disorder, sample collection is more difficult than for other, more common, autoimmune diseases. We hope that with more samples from patients, we'll be able to link more genetic regions to the disease, and it will become easier to identify underlying pathways that could act as therapeutic targets."
Three of the genetic regions associated with PSC fall within a single biological system that underlies variation in T cells, cells important to our immune response. One gene that controls this pathway, HDAC7, is known to be a key factor in immune tolerance and the new data strongly suggests exploring the possibility that drugs affecting HDAC7 function may serve as future therapeutics in PSC.
In an extended analysis, the team identified an additional 33 genetic regions that are also involved in several common immune-mediated conditions (celiac disease, Crohn's disease, ulcerative colitis, type 1 diabetes, rheumatoid arthritis, sarcoidosis and psoriasis). This analysis shows that PSC shares many genetic risk loci with other immune-mediated diseases and opens up the possibility for testing drugs known to be effective in genetically similar diseases for efficacy in PSC.
The next step for the team is to do a high-powered search throughout the entire genomes of PSC patients to find specific regions associated with PSC outside of the regions included on the Immunochip genotyping chip.
"This study has uncovered more about the genetics underlying PSC than any before it, but this is only the first step" says Dr Tom Hemming Karlsen, lead author from Oslo University Hospital, Norway. "We hope the ongoing scientific and clinical research being conducted through the International PSC study group will help improve the outlook for those currently suffering at the hands of this disease"
"Our study, which is the largest of its type for PSC, would not have been possible without the help of the patients with this rare disorder," adds Dr Hemming Karlsen.
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Jimmy Z Liu, Johannes Roksund Hov, Trine Folseraas et al (2013) "Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis"
Advance online publication on Nature Genetics's website on 21 April. DOI: 10.1038/ng.2616
Wellcome Trust Sanger Institute: http://www.sanger.ac.uk
Thanks to Wellcome Trust Sanger Institute for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
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Source: http://www.labspaces.net/127844/Genetics_defines_a_distinct_liver_disease
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