Keep smiling: Collagen matrix promotes gum healing around exposed roots

Public release date: 4-Mar-2012
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Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-203-192-2370
BioMed Central

Receding gums often result in tooth sensitivity and can lead to decay of the root and persistent inflammation of the gum. New research published in BioMed Central's open access journal Head & Face Medicine demonstrates that a novel method using bovine collagen is able to enhance gum healing. This resulted in thicker margins around the tooth and, in over half the cases, complete coverage of exposed roots.

Researchers across Germany and Switzerland led by Dr Shahram Ghanaati and the dentist Dr Markus Schlee investigated the possibility of using collagen, extracted from bovine pericardium, to form a support for mending receding gums and exposed roots. The collagen was extracted by a process involving osmotic, oxidative and alkaline treatment. This ensured that the cell walls were broken down, proteins and fats dissolved, and that bacteria, viruses and other pathogens were inactivated and removed.

The study followed 14 otherwise healthy patients with over 60 'recessions' between them. Their damaged teeth were cleaned before surgery and the collagen implants held in place with loops of surgical thread around the affected tooth. Two weeks later the sutures were removed. None of the patients needed antibiotics.

The patients were re-examined after six months to see how well they had recovered. Dr Schlee described the results, "In all cases the healed-over implant improved the look and severity of the recession, and, in over half of all treatments, resulted in total coverage of the exposed root. We would not have expected any of these patients to get better without surgery."

The collagen seems to be able to act as a scaffold for the body's own cells to repair the damage leading to results on a level comparable to that of connective tissue grafts. Bovine collagen is a possible solution for patients with little available donor tissue or for whom multiple surgeries are not an option.

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Notes to Editors

1. Bovine pericardium based non-cross linked collagen matrix for successful root coverage, a clinical study in human
Markus Schlee, Shahram Ghanaati, Ines Willershausen, Michael Stimmlmayr, Anton Sculean and Robert A Sader
Head & Face Medicine (in press)

Please name the journal in any story you write. If you are writing for the web, please link to the article. All articles are available free of charge, according to BioMed Central's open access policy.

Article citation and URL available on request on the day of publication.

2. Head & Face Medicine is a multidisciplinary open access journal that publishes basic and clinical research concerning all aspects of cranial, facial and oral conditions.

3. BioMed Central (http://www.biomedcentral.com/) is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Science+Business Media, a leading global publisher in the STM sector.

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 4-Mar-2012
[ | E-mail | Share ]

Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-203-192-2370
BioMed Central

Receding gums often result in tooth sensitivity and can lead to decay of the root and persistent inflammation of the gum. New research published in BioMed Central's open access journal Head & Face Medicine demonstrates that a novel method using bovine collagen is able to enhance gum healing. This resulted in thicker margins around the tooth and, in over half the cases, complete coverage of exposed roots.

Researchers across Germany and Switzerland led by Dr Shahram Ghanaati and the dentist Dr Markus Schlee investigated the possibility of using collagen, extracted from bovine pericardium, to form a support for mending receding gums and exposed roots. The collagen was extracted by a process involving osmotic, oxidative and alkaline treatment. This ensured that the cell walls were broken down, proteins and fats dissolved, and that bacteria, viruses and other pathogens were inactivated and removed.

The study followed 14 otherwise healthy patients with over 60 'recessions' between them. Their damaged teeth were cleaned before surgery and the collagen implants held in place with loops of surgical thread around the affected tooth. Two weeks later the sutures were removed. None of the patients needed antibiotics.

The patients were re-examined after six months to see how well they had recovered. Dr Schlee described the results, "In all cases the healed-over implant improved the look and severity of the recession, and, in over half of all treatments, resulted in total coverage of the exposed root. We would not have expected any of these patients to get better without surgery."

The collagen seems to be able to act as a scaffold for the body's own cells to repair the damage leading to results on a level comparable to that of connective tissue grafts. Bovine collagen is a possible solution for patients with little available donor tissue or for whom multiple surgeries are not an option.

###

Notes to Editors

1. Bovine pericardium based non-cross linked collagen matrix for successful root coverage, a clinical study in human
Markus Schlee, Shahram Ghanaati, Ines Willershausen, Michael Stimmlmayr, Anton Sculean and Robert A Sader
Head & Face Medicine (in press)

Please name the journal in any story you write. If you are writing for the web, please link to the article. All articles are available free of charge, according to BioMed Central's open access policy.

Article citation and URL available on request on the day of publication.

2. Head & Face Medicine is a multidisciplinary open access journal that publishes basic and clinical research concerning all aspects of cranial, facial and oral conditions.

3. BioMed Central (http://www.biomedcentral.com/) is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Science+Business Media, a leading global publisher in the STM sector.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-03/bc-ksc030212.php

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