Wednesday, July 31, 2013

US has 20 witnesses for Manning sentencing phase

FORT MEADE, Md. (AP) ? Military prosecutors say they'll call as many as 20 witnesses for the sentencing of Army Pfc. Bradley Manning, the soldier convicted of espionage crimes for giving classified information to WikiLeaks.

The sentencing phase of Manning's court-martial begins Wednesday at Fort Meade, near Baltimore. The hearing is scheduled through Aug. 23.

The government says as many as half of the prosecution witnesses will testify about classified matters in closed court. They include experts on counterintelligence, strategic planning and terrorism.

The government's case could include evidence of damage the leaks caused to national security and troops in Afghanistan and Iraq.

Manning was convicted Tuesday of 20 counts, including six violations the Espionage Act.

Source: http://news.yahoo.com/us-20-witnesses-manning-sentencing-phase-132240343.html

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Tuesday, July 30, 2013

Power outage caused by curious animal

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Source: www.heartlandconnection.com --- Monday, July 29, 2013
Just under 1,000 Ameren customers lost power Sunday night around 9. ...

Source: http://www.heartlandconnection.com/news/story.aspx?id=927212

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Most Popular Car GPS Unit: Your Smartphone

If you're planning a road trip, there are plenty of things you want to take with you, and a good GPS should be one of them. Last week we asked you for the best, and then we looked at the five best car GPS units. We put them to a vote, and now we're back to highlight the winner.

Most Popular Car GPS Unit: Your Smartphone

It shouldn't be much of a surprise, but the majority of you, close to 62%, prefer using your smartphone for turn-by-turn driving directions and GPS. The idea is that the best GPS device is the one you'll have with you at all times, and the ability to download maps for offline use or GPS apps that download map packs for times when you may be without mobile data make up for the limitations of using your phone for GPS.

However, not all of you agreed that a smartphone is the way to go when you're trying to get from point a to point b. Close to 23% of you preferred Garmin's Nuvi series of stand-alone GPS devices for your car, preferring instead to use a dedicated GPS unit over your smartphone. 10% of you said your car came with an in-dash GPS unit that you prefer, or that you'd rather have a good after-market GPS installed in your dash, that way you could pair it with your smartphone if you wanted to, and get something that does more than just one thing. In fourth place with just shy of 5% of the vote was the Tom Tom Go series of dedicated GPS units, and bringing up the rear with about 1% of the vote was Magellan's RoadMate series.

For more detail on all of the contenders, make sure to head back to our Hive Five feature.

The Hive Five is based on reader nominations. As with most Hive Five posts, if your favorite was left out, it's not because we hate it?it's because it didn't get the nominations required in the call for contenders post to make the top five. We understand it's a bit of a popularity contest, but if you have a favorite, we want to hear about it. Have a suggestion for the Hive Five? Send us an email at tips+hivefive@lifehacker.com!

Photo by Yun Huang Yong.

Related
Best Car GPS?

If you're hitting the road and want to make sure you don't get lost, you could use your phone as your GPS, but there's still room for? Read?

Five Best Car GPS Units

If you're hitting the road this summer, you probably want a solid GPS with you to make getting to your destination a little easier. Whether you? Read?

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/BiHti08vzKY/most-popular-car-gps-unit-your-smartphone-960832986

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Apple TV, Google Chromecast And Aereo Put Broadcast Television On Death Watch

Over the last few years, there has been a significant shift in how we consume digital content from music and movies to books and television (TV). The intersection of new technologies, devices and high speed networks has served to accelerate that change, particularly for TV. If we were to hop into the way back machine, it?s hard to believe that TV consisted of only a handful of channels, programming ceased at some point each night and the picture was in black & white, not color let alone 3D. Yet for all the changes we have seen, the recent past and the coming future are poised to radically shift TV to the point that other than live sporting events and maybe news, we may not be able to recognize broadcast TV any longer.

Video on demand (VOD) has become a staple of the cable companies ranging from Comcast Comcast and Verizon Communications Verizon Communications to Cablevision Cablevision and Charter Communications Charter Communications. Streaming services from not only Netflix Netflix and Apple Apple, but also from the aforementioned Comcast and Verizon Communications (check their iPad apps) and HBO as well as others is fueling not only the time shifting consumption of content we have come to rely on in this post Tivo world, but also fostering place-shifting as well. Watch any teen or ?tween and they firmly expect to watch what they want, when they want but where they want and on the device they want.

With smartphone penetration well past the tipping point and tablet sales maturing, many companies are turning their sights on the next battlegrounds. One of them is the Connected Car and another is the Connected Home. Inside that Connected Home, there will be several battlegrounds ? security, home automation (temperature, appliances and so on) and the living room. How that all shakes out has yet to be determined, but rest assured while companies like AT&T, Verizon, and ADT are working on the first few, Apple, Google Google, Microsoft Microsoft, Slingbox, Roku and others are targeting the living room as part of their digital content offering.

Apple TV. Apple has shipped more than 13 million Apple TV units and at the recent D11, CEO Tim Cook shares that TV is not just a hobby, but rather the company has a ?grand vision.? Rumors over the next iteration of Apple TV continue and before too long that rumor mill is likely to kick into high gear once again as Apple prepares for the official unveiling of iOS 7. Like the soon to be released iRadio, Apple TV is a work in progress, which means we keeping our eyes and ears open on this digital content streaming and portal device. Combined with the full power of Apple?s digital hub ? iTunes ? it could be a powerful new weapon for Apple as well as a very sticky one for consumers.

Google?s Chromecast. Last week, Google introduced a potential game changer to media consumption in the form of Chromecast, a $35 thumb drive sized device that that plugs into the back of your TV, allowing you to stream content from any device. Well almost any device. If you have an Android tablet or smartphone, an iPad or iPhone, use Chrome for Mac and Windows then you are in luck. If you use a BlackBerry or Windows Phone,? at least for now you will be stuck using either a PC or tablet. This just introduced product has already sold out online at Best Buy, Amazon.com, and Google Play.

Aereo ? one to watch. While both Apple TV and Chromecast allow for the streaming of TV and other digital content, it is Aereo that has or at least should have the major broadcast ? TV networks ? Walt Disney Walt Disney?s ABC, CBS CBS, Comcast?s NBC and News Corp News Corp.?s Fox ? concerned if not? worried.

Backed by IAC?s Barry Diller, Aereo is a Web video service that offers local TV channels and a DVR-like service, which can be viewed on a PC or Mac, iPad, iPhone, Apple TV or Roku device.? While Aereo doesn?t support Android as yet, given the existing support for Google?s Chrome browser one has to wonder how long until it and Chromecast are supported. Currently offered in New York, Boston and Atlanta, Aereo has plans to expand to another 20 markets, with Salt Lake City in August and Chicago in September.

Arguably, success at Aereo poses a problem for the broadcast industry in that it collects fees to the tune of billions by allowing cable networks access to local channels. Like any company that sees a high margin revenue stream under potential attack, last March, broadcasters filed two federal lawsuits accusing the service of violating copyright law. In March, a New York federal appeals court upheld a ruling in favor of Aereo. Given the fees and profits at stake, it?s more than likely we have not heard the last of this. I for one can?t wait to sample Aereo?s service as the company expands its footprint in the coming months.

How to invest in this? Whenever I see so many companies looking to compete in one market, I tend to step back and look at the food chain or ecosystem for those players that offer critical solutions vs. commodity components and serve many of the would be players. A great example of such a merchant supplier in the smartphone and tablet space is Qualcomm Qualcomm, which counts Samsung, Apple, LG, HTC and most if not all the other key players as customers.

In this digital content and Connected Home battleground, the teardown analysis on the latest Apple TV unit and on a Chromecast performed by iFixIt.com as well as similar analysis on the Roku 3 and the Slingbox 500 reveal key supplier to be Toshiba, Broadcom Broadcom, Marvell Technology Group Marvell Technology Group, Micron, Atheros (now owned by Qualcomm) and AzureWave (TPE:3694). Toshiba and Micron are supplier of NAND flash memory, while the key connective technologies are provided by Broadcom Broadcom, Marvell and Atheros/Qualcomm. It?s the latter group of companies that investors should be focusing on.

?

Disclosure. Subscribers to PowerTrend Profits were alerted to the long-term investment opportunity in Qualcomm shares on April 9th.

Source: http://www.forbes.com/sites/chrisversace/2013/07/29/apple-tv-google-chromecast-and-aereo-put-broadcast-television-on-death-watch/

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Monday, July 29, 2013

rock n roll: Structured Settlements in Workers' Compensation


Self-insured employers often question how to resolve their high value and difficult to conclude claims. The financial expectations and medical needs of the injured employees create complicated issues preventing a claim settlement. Structured settlements can often be the bridge to achieving a settlement when the injured employee will have on-going financial and medical needs.

We have received many questions about the benefits of structured settlements and how to achieve a structured settlement.? Here are the most frequently asked questions about structured settlements.

Q. Exactly what is a structured settlement?
A. A structured settlement is financial agreement for a series of periodic payments an injured person receives over a set time period, or over the person?s life time, to settle any legal obligation, including a workers? compensation claim.

Q. Are all payments the same?
A. All payments can be the same, but often are flexible and will vary to meet the financial needs of the injured employee. For instance, in addition to biweekly or monthly payments to cover the employee?s on-going loss of income, an initial lump sum to cover transportation or housing needs can be included in the structured settlements. Other variations from the biweekly or monthly payment can be included, for example a future sum for the college tuition of the employee?s child.

Q. What about inflation? How does the structured settlement handle the future decline in purchasing power?
A. The structure settlement can be structured to increase the periodic payment amounts by a fixed amount on a fixed date(s) in the future.

Q. Workers? compensation indemnity payments are ?tax free?. Will the injured employee have to pay income taxes on the periodic payments?
A. No. Under the provisions of the Internal Revenue Code Section 104(a)(1), the periodic payments of a structured settlement are income tax free.

Q. Why would an employer obligate itself to a set of periodic payments that could last for many years into the future?
A. The employer purchases a fixed annuity from a life insurance company to fund the future periodic payments. The life insurance company assumes the responsibility of making all future payments. The employer obligation to make the payments is transferred to the life insurer eliminating the employer?s need to set aside any future reserves for the workers? compensation claim.

Q. What type of workers? compensation claims benefit from the use of a structured settlement?

A. An employer can reduce their long-term financial exposure on any serious or catastrophic injury claim with a structured settlement. Examples of cases that often involve a structured settlement include:

??? Brain/brain stem injuries
??? Spinal cord injuries
??? Amputations
??? Severe burns
??? Multiple trauma claims
??? Vision loss
??? Hearing loss
??? Occupational lung diseases
??? Any type of injury that leaves the employee permanently and totally disabled or disabled to the point the employee is unable to return to meaningful employment.

Q. How do structured settlements account for the medical expenses of an injured employee that could last a life time?
A. A separate medical account is set up to cover the employee?s future medical expenses as established by medical actuary. A third party professional administration company oversees the payment of future medical expenses from the account.

Q. What about an injured employee who is eligible for Medicare and/or Social Security Disability? How does a structured settlement handle the requirements for a Medicare Set-Aside (MSA) arrangement?
A. A structured settlement is highly beneficial for a MSA. A structured settlement for the MSA benefits the employer as it costs less because the MSA benefits from the time value of money. Instead of the third party professional administration company receiving all of the money for the MSA up front, the structured settlement insurer funds the MSA periodically as needed.

Q. What information is needed by the structured settlement company before they can quote the cost of the structured settlement?
A. There are several factors that come into play in calculating the cost of the structured settlement including the injured employee?s age, the expected life expectancy of the injured employee, the anticipated cost of future medical care and the employee?s need for lump sum payments both at the start of the structured settlement and at future specific dates.

Q. How can the employer know the life insurance company will be able to make the periodic payments twenty, thirty or forty years in the future?
A. The employer can check the life insurer?s financial strength through the service of A.M. Best, an independent evaluator of the financial strength of insurance companies. We recommend the use of an insurer rated A, or higher, by A. M. Best.

Q. What benefits does a structured settlement provide to the injured employee?
A. There are many benefits to the injured employee, including:

??? The structured settlement eliminates many of the financial concerns of the employee by allowing the employee to know what his/her future income will be.

??? The employee can receive payments both for immediate needs and periodic payments timed to meet future anticipated needs.

??? The employee does not have to worry about managing a large amount of money or fluctuations in the equity market or bond market.

??? The employee is provided is a provided a good fixed rate of return on the money invested in the structured settlement.

??? In most cases, the structured settlement provides the employee with more money over the long term than a lump sum settlement paid direct to the employee.

??? The employee/employee?s attorney no longer has to interact with the employer where the relationship may have become strained, but instead will interact with the life insurer who provides the structured settlement.

??? Also, if the employee invests a lump settlement on their own, the employee will be responsible for income taxes on the interest, capital gains or dividends earned by their investment.

Q. Are there any other reasons the injured employee would want a structured settlement?
A. There are several reasons an employee would prefer a structured settlement over the benefits provided by the workers? compensation system. Structured settlements give the employee freedom from the restraints of workers? compensation.

The workers? compensation payments have a time limit in many states (often 400 weeks or 500 weeks) after which the payments cease.

Statutory payments in death claims normally cease upon remarriage.

Workers? compensation indemnity payments can end if the employee is retrained for another job and returns to work in another field.

Q. The employee is represented by an attorney. How are the plaintiff attorney fees handled?
A. The plaintiff attorney fee can be paid as a lump sum settlement or the attorney fees can also be set-up in a structured settlement providing the attorney with a guaranteed source of future income.

Q. The closure of the claim through a structured settlement is the major benefit to the employer. Are there other benefits to the employer?
A. Yes. A structured settlement can avoid the uncertainty of litigation and end the on-going legal expense. In life time disability claims, the mortality risk and the investment risk is transferred to the life insurer. Also, the cost of funding a Medicare Set-Aside can be reduced through the use of a structured settlement.

Q. Other than workers? compensation claims, are there any other uses for structured settlements?
A. Yes, structured settlements are often used to resolve a wide variety of litigated matters including:

??? Long term disability claims
??? Automobile injuries
??? Product liability claims
??? Slip and fall injuries
??? General liability claims
??? Medical malpractice claims
??? Legal malpractice claims
??? Errors and Omissions claims
??? Wrongful death claims
??? Nursing home abuse claims
??? Punitive damage claims
??? Slander and libel claims
??? Construction defect claims
??? Disputed property claims
??? Sexual harassment claims
??? Age discrimination claims
??? Employment discrimination claims
??? Wrongful termination claims
??? Guardianship cases involving minors or incompetents
??? Environmental pollution claims
??? ? ? Asbestos
??????? Mold
??????? Lead
??????? Toxic chemicals

source: reduceyourworkerscomp.com

Source: http://rocknrollmusiczep.blogspot.com/2013/07/structured-settlements-in-workers.html

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At least 36 dead after coach plunges off viaduct in Italy

ROME (Reuters) - At least 36 people died after a coach plunged more than 15 meters (49 feet) off a viaduct in southern Italy on Sunday, a spokesman for the fire service said.

Eleven people were pulled out alive from the stricken coach and taken to hospital, some with serious injuries, the spokesman said.

Rescue operations are ongoing, he said.

The coach was carrying about 48 people back to Naples after visiting Telese Terme in the southern region of Campania, Italian daily La Repubblica reported.

"The situation is dramatic," the spokesman for the fire service said, adding that several other vehicles were also involved in the accident.

(Reporting By Catherine Hornby; Editing by Alistair Lyon, Philip Barbara and Stacey Joyce)

Source: http://news.yahoo.com/least-36-dead-coach-plunges-off-viaduct-italy-001133348.html

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Thousands of bees attack Texas couple, kill their horses

A swarm of about 30,000 bees has attacked a North Texas couple as they exercised their miniature horses, stinging the animals so many times they died.

The Fort Worth Star-Telegram reports 44-year-old Kristen Beauregard was stung about 200 times and her boyfriend about 50 times.

Beauregard says the swarm chased them down and followed them. She says they were sweeping up piles of bees "like a bad movie."

She says firefighters sprayed a foam substance to clear the bees, and dragged the horses to a pasture to be treated by police and paramedics.

A 6-year-old show horse died before a veterinarian arrived. A Shetland pony spent a night at a veterinary clinic but also died.

The bees are being tested to see whether they are Africanized or "killer" bees.

Source: http://feeds.foxnews.com/~r/foxnews/national/~3/JoetgeyuAQo/

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At least 24 dead after coach plunges off viaduct in Italy

ROME (Reuters) - At least 24 people died on Sunday after a coach plunged more than 15 meters off a viaduct in southern Italy, a spokesman for the fire service said.

Eleven people have been pulled out alive from the stricken coach and taken to hospital, some with serious injuries, the spokesman said.

The coach was carrying more than 40 people back to Naples following a pilgrimage in the southern region of Campania, Italian daily La Repubblica reported.

"The situation is dramatic," said the fire service spokesman, adding that several other vehicles had also been involved in the accident. Rescue operations are ongoing.

(Reporting By Catherine Hornby; Editing by Alistair Lyon and Philip Barbara)

Source: http://news.yahoo.com/coach-plunges-off-viaduct-italy-several-dead-injured-220359267.html

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Sony to host Gamescom conference on August 20 at 6pm BST

Posted 2:01pm on Fri 26 July 2013

VG_Staff
Posts: 22,625
Expect more details on the PS4, perhaps a release date.

Read News

Posted 2:01pm on Fri 26 July 2013

DASHONFIRE
Posts: 7
I thought I was going to miss this because I'm going to Leeds festival but I'm not going till the Wednesday so I'll be able to watch it live woop!

Source: http://community.videogamer.com/forums/article_comments/sony_to_host_gamescom_conference_on_august_20_at_6pm_bst/?goto=new

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Sunday, July 28, 2013

Rice head coach: ?40 dollars if you ask me anything else about Johnny Manziel?

Texas A&M quarterback Johnny Manziel has been the talk of many conversations around college football this offseason but his name has come up more among opposing coaches than fans.

That was proven even more true last week when Rice head coach David Bailiff was asked at Conference USA?s Media Day how many times he?s asked about Manziel.

?Every day,? Bailiff told the media, according to Drew Champlin of al.com. ?I get where I tell them, ?It?s 40 dollars if you ask me anything else about Manziel.??

Bailiff?s Owls will travel to take on Manziel and the Aggies in the season opener Aug. 31 at Kyle Field with kickoff set for noon.

The Rice coach did however point out that in order for his team to play straight up against the Aggies, they would have to focus on more than just the record setting quarterback.

?With Manziel, we?ve talked about how it can?t be about Manziel, it has to be about A&M,? Bailiff said. ?We have to worry about getting us better. When we walk off that football field, we want to make sure we?re a better football team in Week 2 than Week 1.?

Source: http://collegesportsblog.dallasnews.com/2013/07/rice-head-coach-40-dollars-if-you-ask-me-anything-else-about-johnny-manziel.html/

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Saturday, July 27, 2013

Ugandans honour Australian aid worker Irene Gleeson, who died of cancer aged 68

Updated July 27, 2013 14:45:06

Up to 10,000 people have attended a memorial service in Uganda to celebrate the life of an Australian woman who cared for a generation of children traumatised by war.

Irene Gleeson dedicated more than 20 years of her life to helping orphaned children and those abducted by Joseph Kony's Lord's Resistance Army.

The 68-year-old died in Sydney last week from cancer.

Uganda's foreign minister and several MPs were among the mourners who attended the service on the grounds of the Irene Gleeson Foundation at Kitgum in the country's north.

During two decades on the frontline of war, Ms Gleeson fed, housed and educated an estimated 6,000 orphans or destitute children.

During much of that time she lived alone in a caravan at Kitgum, but built several primary schools and two vocational colleges.

Her passing is of deep significance to the region's people, who affectionately knew her as Mama Irene.

The nation's foreign minister, Henry Okello, says northern Uganda would be a very different place if Ms Gleeson had not dedicated her life to helping others.

The government is now being asked to consider honouring Ms Gleeson as a hero of Uganda.

Jean Paul, the chief executive of the Irene Gleeson Foundation, says he is going to continue the work that she has done.

"Today is a day of celebration. Our hearts are broken. We are in pain. We lost our mother. The entire nation has lost a mother," he told the ABC.

"But also we are here not just to mourn but to celebrate the life of Mama Irene. The lives she has changed.

"The landscape she has transformed, the nation she has blessed, the thousands of children that she has given hope to who would have perished without her sacrifice of leaving her home in Australia, selling it and relocating to the war zone of Uganda.

"We have received thousands of mourners who have come to pay their last respects to Mama Irene. We have district officials, representatives of the Australian High Commission in Nairobi are here. It is a big day.

"The people are asking that this day be remembered every year, the day Mama Irene passed on, 21 July every year, we come together and remember it.

"Yes, we are in pain. We are hearing testimonies of children who have been built to their full potential by Mama Irene.

"But also we are not just going to mourn. Mama Irene say: 'Never say, rest in peace, for me'. Because for her, she will be dancing and singing in heaven.

"We know she will be proud to see the people here today and the lives changed through her work."

Topics: people, human-interest, unrest-conflict-and-war, uganda

First posted July 27, 2013 13:46:36

Source: http://www.abc.net.au/news/2013-07-27/ugandans-honour-australian-air-worker-irene-gleeson/4847896

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Four more women accuse San Diego mayor of sexual misconduct

SAN DIEGO | Fri Jul 26, 2013 3:37am EDT

SAN DIEGO (Reuters) - Four more women, including a retired U.S. Navy admiral and a college dean, came forward on Thursday to publicly accuse San Diego Mayor Bob Filner of making unwanted sexual advances toward them, as local party leaders called on him to resign.

The latest allegations leveled at Filner during a group interview of the four women by public television station KPBS brought to seven the number of women who have come forth since earlier this week to accuse the 70-year-old Democrat and former congressman of sexual harassment.

Meanwhile, the San Diego County Democratic Party Central Committee voted 34-6 to approve a non-binding resolution calling on Filner to step down.

(Reporting by Marty Graham; Writing by Steve Gorman; Editing by Eric Beech)

Source: http://feeds.reuters.com/~r/reuters/topNews/~3/B_AmJ6PcHbc/story01.htm

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Android 4.3, Chromecast, DSLR Secrets, and the Ultimate Photoshop Rig

This week on the podcast we're talking about Android 4.3, the new Chromecast device from Google, and how stores are tracking you through your phone. We're also answering your questions about mechanical keyboards, when to use apps instead of mobile sites, and building the ultimate Photoshop PC.

How to Listen to This Week's Episode

Here's how you can listen to our episode:

News and Top Stories

  • What?s New in Android 4.3 Jelly Bean Today, Google finally took the wraps off the new version of Android it neglected to announce back at I/O (instead releasing new features via Play Services instead). Here's what's new.

  • Google Unveils the Chromecast, an HDMI Stick for Streaming Video Google took the wraps off of the Chromecast today, a tiny thumb drive-sized stick with an HDMI port on one end that's Wi-Fi enabled. It's designed to make it simple to push video from your home network, smartphone, or the web right to your TV screen.

  • Gmail Has New Ads That Look Like Emails, Here?s How to Turn Them Off When Google introduced the new tabbed interface for Gmail, it also brought along some new ads under the Promotions tab.

  • How Retail Stores Track You Using Your Smartphone (and How to Stop It) When you walk into a brick and mortar retail store like a Nordstrom, Cabela, or even Family Dollar, you're being tracked around the store. Not by an over-suspicious security guard, but by the store's wireless network, using your phone's Wi-Fi. The store then uses your phone to track you around the store, determine if you're a repeat visitor, see what departments you visit, and more. Here's how they do it, and how to stop them.

  • The Awesome DSLR Features You (Probably) Never Knew Existed When compared to point-and-shoot cameras, DSLRs come with the promise of superior image quality and increased shooting flexibility. It?s much more than that, though: many upgrade and completely miss major benefits of using a high-end camera. If you?ve got a DSLR, make sure you know about these features before you take another photograph. (If you?re new to DSLRs, check out our Photography Night School course first!)

  • When Should I Use Credit and When Should I Use Debit When Shopping? Dear Lifehacker, When I'm out shopping, I'm always presented with the option to use debit or credit when I check out. I've heard there are benefits to using credit, but aren't there fees involved that can drive up the price or put a strain on the owner of the shop I'm in? When should I use which? Is there even a difference?

Questions and Answers

  • David writes, ?It seems like most of the web sites I visit from my Android phone want me to install the app rather than visit their site with a web browser. But I really don't like wasting storage space installing apps with redundant functionality. Is there a compelling reason for me to install the Facebook, IMDB, Feedly, HipChat, LinkedIn, Wikipedia, or Amazon apps instead of just using Android Chrome like I'm doing now??

    A lot of the time mobile apps work better than the ones you get from their respective app stores. If you really want the native app experience, however, check out third-party apps for services (e.g. Reddit, Facebook, Twitter) as they might give you the experience you want out of an app. But if you like the mobile sites you should just use those. They work just as well, if not better, most of the time.

  • How can I test out mechanical keyboards?

    We don't really rely on online views a ton anymore because they just aren't very reliable. The easiest way to solve the problem?presuming you can't find a store that carries them?is to buy a bunch of keyboards and return the ones you don't like.

  • WannaBeGeek writes, ?Your build a PC guide talks about gaming intensive and normal use. What if I want a build for Photoshop? I thought it would be similar, but from my limited research on Google, it looks vastly different (e.g. they have 4 hard drives: boot & programs, photoshop output, scratch disk, storage).?

    Get a mid-range graphics card, a fast CPU, an SSD for your boot disk, a separate disk for a scratch disk (either a small 64GB+ SSD or small hard drive), and additional disks for backup (if needed).

Tips of the Week

Downloads of the Week

How Do I Submit a Question?

There are two ways to send in your question:

Please keep your questions as brief as possible. This means about 3-5 sentences for emails and 30-60 seconds for calls and videos. Your questions can be specific, but broader questions are generally better because they'll apply to more people. For example, "how can I breathe new life into my old PDA?" is much better than "what can I do with an old HP iPAQ 210?" Either way, we look forward to hearing from you!

RelatedRelatedRelatedRelatedRelatedRelatedRelatedRelatedRelatedRelatedRelatedRelatedRelated

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/eFwXXV6WteI/android-4-3-chromecast-dslr-secrets-and-the-ultimate-915586347

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Undeniable Sabotage (talking-points-memo)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS Feeds and Widgets via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/321772669?client_source=feed&format=rss

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Friday, July 26, 2013

What Services to Expect in a Memory Care Community | Find Senior ...

If your loved one is struggling with Alzheimer?s or dementia, they may require additional services that a regular assisted living community cannot provide. Many senior living communities have special sections, sometimes called ?villages,? reserved for residents who need specialized ?memory care.?

What services should you expect when a loved one moves into a memory care community within an assisted living facility?

Heightened Security
Memory care villages will often have locked gates that permit residents to enjoy a sense of freedom and independence on the facility?s grounds, but permit them from leaving the community, where they could get lost or injured.

Additionally, security staff will be trained to gently re-direct Alzheimer?s and dementia patients if they begin wandering from planned activities or straying too far from their daily schedule.

Additional Monitoring and Safety Practices
Some Memory Care communities have trained staff or Certified Nurses who can actually dispense medication, rather than offering medication reminders. These individuals also monitor the behavior and activities of residents, and can report dramatic changes in personality, behavior or health to primary care physicians or get emergency medical attention for a resident if needed.

Rooms are designed so that residents can stay safe while living alone and getting the personal care services they need.

Trained Staff
Dealing with Alzheimer?s and dementia patients requires compassion and special training. Dignity, freedom and independence are important to all Assisted Living residents, but caring for residents with Alzheimer?s represents unique challenges; there is the constant threat that a resident may hurt him- or herself, become agitated for no apparent reason, or even forget where they are.

Staff is trained to manage individuals with Alzheimer?s better than unpaid caregivers and family members can do at home.

Activities Tailored to Preserving Cognitive Function
The brain is a muscle, and studies show that one way to reduce Alzheimer?s and dementia symptoms is to give individuals an opportunity to exercise that muscle by using their mind. Memory care facilities provide an activities program that is tailored to helping individuals slow the progression of the disease and remain as independent as possible for as long as possible. This includes sensory stimulation, cognitive therapies, and physical and occupational therapies.

Many of these are performed in group settings, giving residents the socialization they need, as well. Of course, regular exercise, which has also been shown to slow the progression of Alzheimer?s, is included in Memory Care activity programs.

Music and art therapy is often used frequently, sometimes in conjunction with other therapy programs, as it?s been shown to reduce aggression and agitation in Alzheimer?s and dementia patients.

Great efforts are taken to keep memory care patients on a regular routine, since this type of stability, knowing what to expect each day, diminishes agitation in those who suffer from Alzheimer?s and other forms of dementia.

Nursing Home vs. Assisted Living Memory Care
Unlike an Assisted Living community, a nursing home offers 24/7 services and can manage patients who are unable to care for themselves at all. If you or a loved one suffering from Alzheimer?s can still perform many Activities of Daily Living (ADLs), albeit with a little help, assisted living provides greater independence than a nursing home.

Individuals with Alzheimer?s may thrive in an Assisted Living community tailor made for memory care, even better than they might at home. The additional services and therapies available can slow the progression of the disease and offer the right balance of independence, safety and security that seniors with Alzheimer?s need.

SeniorLiving.Net is a free service for families to use that are looking for senior care or senior living for a loved one. Call (866) 662-0435 to speak to your local Care Advisor about senior care providers in your local area.

?

Source: http://www.seniorliving.net/categories/memory-care/what-services-to-expect-in-a-memory-care-community/?utm_source=rss&utm_medium=rss&utm_campaign=what-services-to-expect-in-a-memory-care-community

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Thursday, July 25, 2013

BCS leagues turn sour on NCAA regulations



Southeastern Conference Commissioner Mike Slive was critical of the NCAA during the 2013 SEC media days. (Halifax Media Group | File)

By RALPH D. RUSSO
Associated Press

Published: Tuesday, July 23, 2013 at 10:40 p.m.
Last Modified: Tuesday, July 23, 2013 at 11:03 p.m.

NEW YORK ? The five power conferences are trying to redefine what it takes to operate a Division I college athletic program, with their commissioners calling out the NCAA at media days around the country.

Big 12 Commissioner Bob Bowlsby and fellow commissioners Mike Slive of the Southeastern Conference and John Swofford of the Atlantic Coast Conference have taken turns critiquing the NCAA over the last week, and it's likely Jim Delany of the Big Ten and Larry Scott of the Pac-12 will follow suit in the coming days.

The schools in the most powerful and wealthy leagues want more freedom to be able to run their programs the way they want, without the less powerful schools standing in the way.

Does this mean the end of the NCAA as we know it is near? Or will there be a new division of college football ? Division 4 as Bowlsby calls it? Not necessarily.

Former Big 12 Commissioner Dan Beebe said he thinks Atlantic Coast Conference, Big Ten, Big 12, Pac-12 and Southeastern Conference can get the power to govern themselves without cutting off all ties to schools from the less powerful and wealthy FBS conferences.

And NCAA expert John Infante, who writes the ByLaw Blog at athleticscholarship.com, says the best solution for the schools in those conferences is not leaving Division I, but reshaping it in a way where some smaller schools choose to leave. The lightning rod issue at the heart of this debate has been the proposed stipend to college athletes that would add about $2,000 to an athletic scholarship to cover the full cost of attendance.

All the commissioners from the major conferences have pushed for it, but it could not be passed because smaller schools said they couldn't afford it. So, a possible solution for the powerful, wealthy schools is to set up a level of football at which all the participating schools gave players stipends ? and let the smaller schools play each other.

The programs that would be most affected by the big five isolating itself from the rest of college sports would be from the lesser leagues in college football's top tier: the Mountain West, the American Athletic Conference (formerly the Big East), Conference USA, the Sun Belt and the Mid-American Conference.

Those schools still want to compete against the big five on the field, cash in on the monster pay days that usually come with playing those games and capitalize on the attention that comes when they occasionally win one.

The FBS conferences will share, though not equally, the $5.6 billion ESPN is set to pay over 12 years for broadcast rights to the College Football Playoff.

The big five conferences will take 75 percent of that money, but the 25 percent left over for the other five to split still represents a big raise from what they were making under the BCS. Presumably, the power conferences would make even more breaking away. But it might not be quite that easy.

?What happens when these 70 schools break away and form Division 4? Might happen. I don't think it's going to happen,? Mountain West Conference Commissioner Craig Thompson told reporters at his league's football media day in Las Vegas.

MAC Commissioner John Steinbrecher said at media day in Detroit: ?The question is, can we come to agreement on a set of rules that allows us to co-exist amicably? I tend to believe we can.?

Beebe thinks so, too.

He said the big five ultimately will be allowed to allocate their enormous resources toward providing more money for student-athletes and they will be able to increase academic standards the way they see fit.

?It's going to be done but the competition is going to go on on the court and field,? said Beebe, who now heads a sports consulting firm called the Dan Beebe Group.

Infante said if the big five gets its way, it could lead to a culling of Division I, which currently includes 349 schools, with some of the 125 FBS schools dropping down to FCS, major college football's second tier. Infante added the big five creating a new division of college athletics might not be so well-received by the lower-revenue members of their own leagues, schools such as Iowa State and Mississippi State that would become the new have-nots of major college football.

Also, the potential backlash from FBS schools in the group of five who were no longer considered major college football schools also could be blunt movement toward the big five separating from the rest of Division I.

Source: http://www.gadsdentimes.com/article/20130723/wire/130729923

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A long-time Apple bull no more

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FORTUNE -- One longtime Apple bull doesn't sound so bullish on Apple now.

Appearing at Fortune's Brainstorm Tech conference in Aspen, Colo., hedge fund manager Phillippe Laffont of Coatue Management sounded lukewarm at best when asked about Apple's (AAPL) prospects. At the end of March, Apple represented 6.71% of the $7.9 billion fund, good for the fifth largest position.

A few months ago, Laffont told Bloomberg TV that Apple's stock was cheap by any measure.

But when asked at Brainstorm Tech?whether Apple has a bright future, Laffont said that "the stock reflects great uncertainty about whether the best days are over." The fact that the markets for tablets and smartphones are already saturated in developed markets, he said, concerns him. As well as the fact that Apple has alway been intent on developing new technology in-house -- a luxury that he's not sure the company can afford anymore. "Apple just seems like everything has to be invented there," said Laffont. "That gets me really worried."

MORE:?Uber is starting to look like a lifestyle brand

Laffont, known as a "Tiger Cub" because he is a protege of legendary hedge fund manager Julian Robertson of Tiger Management, said that investing in tech is actually pretty simple. He tries to identify big trends and then makes bets on them. One big idea he's betting on now is the ramp-up in data capacity in homes. In the competition to provide that capacity, "we think the cable companies are in a good position." He also likes the phone tower business, because of the demand for LTE service.

What is he not bullish on? The road leads back to Apple's core business. "The theme we don't like so much is the people that make the phones and tablets," said Laffont. "But content, we love content. Everyone has a screen and they want more content." The bottom line: "Content, mobile broadband, yes. Hardware and anything related to PCs, no."

Apple shareholders can take solace in the fact that there is at least one stock that Laffont likes less than Apple right now. "I wouldn't buy Intel (INTC) at any price," said Laffont.

Source: http://rss.cnn.com/~r/rss/money_topstories/~3/2dMZ_26qBnY/

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Wednesday, July 24, 2013

Cape May mayor wants 'Coast Guard Community' designation for town

CAPE MAY ? Mayor Ed Mahaney remembers when the U.S. Coast Guard recruit training center almost left town. He doesn?t want that possibility to emerge again.

So Mahaney is pushing for a congressional declaration of Cape May as an official Coast Guard Community.

?It could help keep them here,? Mahaney said.

The Coast Guard certainly felt welcome here in 1998, when 700 residents showed up for a town meeting urging the Coast Guard to stay when it was considering relocating. There also had been efforts to move the Coast Guard?s only boot camp for enlisted personnel in 1982 and 1995. The issue comes up every so often, usually when the Coast Guard faces budget cuts and wants to consolidate bases.

Designating the town as a Coast Guard Community, which has been issued for 14 other places in the country that host Coast Guard facilities or have special significance to the service, may help. It would certainly make the Coast Guard feel welcome.

Such proclamations are usually given to communities that go out of the way to help the Coast Guard. Under 1998 federal legislation, a city or county can apply to become a Coast Guard community. The decision is made by the Coast Guard commandant with congressional review.

?It?s not what the Coast Guard has done for the community. It?s how much the community has done for the Coast Guard,? said Chief Warrant Officer Donnie Brzuska, who handles public affairs at Coast Guard Training Center Cape May.

The community submits an application outlining what it does for the Coast Guard.

?The information is there. You have to get it all together and tell the story, convincingly and succinctly,? said Capt. Todd Prestidge, the commanding officer of the base.

Mayor Mahaney notes that 2,000 people either serve at the base or are civilian employees. Many are involved with the town. Coasties, as they are known, serve on the local school board that oversees a school with more than half the students coming from the base. The base is the largest single employer in town. Coast Guard children are on the Cape May Waves swim team. The Coast Guard marches in local parades and shows up every year to help clean up the shores of Cape May Harbor.

?They?re a large part of our population and economy. We wouldn?t have a school without them. They are involved in social, recreational and civic activity. They shop in our stores, their children play on our teams, and their family members are employees,? Mahaney said.

Coast Guard graduations, held almost every week, annually bring an estimated 40,000 visitors who stay in local hotels, dine in restaurants and shop. Coasties on liberty on Saturdays shop in local stores and often travel up to Rio Grande, Middle Township, to that shopping district. Coast Guard uniforms are made at a facility in Woodbine.

The impact of the Coast Guard presences is felt beyond city limits, and Cape May County Freeholder Will Morey has gotten involved with the application to see if the entire county can become a Coast Guard Community.

?Clearly, it?s a relationship that?s regional,? Morey said. ?We wrote all the mayors. The Cape May County Chamber of Commerce is involved as well, writing to business people and asking for an inventory of what they do for the Coast Guard.?

The Coast Guard Community application will include Operation Fireside, an effort by the American Red Cross in Cape May Court House to place recruits in local homes for a Thanksgiving and Christmas meal. It will include the discounts offered at Cape May hotels for families of recruits coming to boot camp graduations.

It will include the scholarships offered to Coast Guard children at summer programs at The Nature Center of Cape May. It will include a program to allow Coasties to use the Stone Harbor beaches. It will include Cape May providing police and EMT services to base housing on the east side of town. These are just a few examples.

Brzuska said there are some things that will be harder to get in the application package but are significant.

?It?s the love and support for the Coast Guard deeply ingrained in this community. You see it every day. It?s the free cup of coffee, the person who stops you and thanks you for your service, and the thunderous applause as we march in the Christmas parade. The city has to demonstrate that. It?s not really about dollars. It?s about love of the Coast Guard,? Brzuska said.

It could be argued that the Coast Guard has been a presence here almost since the county?s birth. The U.S. Revenue Cutter Service, a predecessor agency of the Coast Guard, assigned the two-masted cutter General Greene to patrol the Delaware Bay in 1791.

The modern Coast Guard emerged in 1915, and since then, Cape May has hosted what was once the largest Coast Guard air base and now hosts the nation?s only recruit training center. The air base, which moved to Egg Harbor Township in 1998, was sited here in 1926 initially with three amphibious biplanes.

Coast Guard training began at the base in 1948. The Coast Guard also constructed a Loran navigation station across Cape May Inlet in Lower Township in 1947. Other Coast Guard facilities, including small boat stations and lighthouses, are also part of the Coast Guard presence in the county.

Mahaney and Morey are chairing a committee that expects to present an application to Capt. Prestidge around Labor Day. Mahaney is hoping the designation comes by Memorial Day.

There is another benefit to the distinction.

Becoming a Coast Guard Community can help with marketing and public relations. The first city to get the designation, Grand Haven, Mich., advertises itself as ?Coast Guard City USA.? Brzuska said it creates ?branding opportunities? that can help draw Coast Guard families for vacations and put Cape May on their radar screen when they seek a place to retire.

Morey sees it as much more than a public relations move. He wants people to link Cape May County and the Coast Guard the way they link Annapolis with the U.S. Navy. He wants to look into putting a national Coast Guard museum here.

?This is not PR. This is a move of substance. It?s important culturally, socially and economically. I think we will benefit from it, and it?s the right thing to do,? Morey said.

Source: http://www.stripes.com/news/coast-guard/cape-may-mayor-wants-coast-guard-community-designation-for-town-1.231679

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Amanda Bynes Is Getting Psychiatric Help... Involuntarily

It wasn't long ago that Amanda Bynes was on top of the world, thanks to TV hits like The Amanda Show and What I Like About You, and roles in the films What a Girl Wants and Easy A. But then the actress dropped out of the spotlight -- until a few months ago, at least.

Source: http://www.ivillage.com/amanda-bynes-hospitalized-5150-psychiatric-hold/1-a-542421?dst=iv%3AiVillage%3Aamanda-bynes-hospitalized-5150-psychiatric-hold-542421

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Alfonso Cuaron Talks Robert Downey's Gravity Departure

4c4436950f7864aa5b10c59066ec2ac31 Alfonso Cuar?n Talks About Why Robert Downey Jr. Left Gravity, Watch Full Comic Con Panel

Alfonso Cuar?n?s Gravity had a great showing this past weekend at Comic-Con, which is impressive since it was competing for our attention against some pretty MASSIVE films. It?s taken almost five years to reach the big screen but the director?s sci-fi thriller is almost here and now that the long journey is behind him,?Cuar?n is starting to open up on why it took the film so long to be completed.

Originally, Robert Downey Jr. was set for the role that George Clooney now has. Though details on why RDJ dropped out weren?t too clear at the time (some pointed to scheduling issues), now we?re receiving a more clear cut picture of what went down.

According to?Cuar?n:

?[It] was very clear that the technology we were going to use? was not the most compatible thing for what Robert is the best at.? Cuar?n said (via?HuffPo). ?That is, he takes one scene and he just starts riffing. And because of the technology that we use, it?s pretty much limited. We have to pre-program the film before shooting.?

You can read the full interview over at HuffPo for more but it?s definitely interesting to hear the real reason behind Downey Jr.?s departure.?Cuar?n does bring up a good point and though it would have been nice to see RDJ in the role, I?m sure that things will work out perfectly with Clooney in the film instead.

In addition to that nice little tidbit of information, we also have a video of the Comic-Con panel for those who missed it. You can check it out below.

Gravity?releases on October 4th, 2013.

Source: http://www.rottentomatoes.com/m/1927931/news/1927931/

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Harry Reid says Mitch McConnell 'tried to make love to the tea party' (Washington Post)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, RSS and RSS Feed via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/321189119?client_source=feed&format=rss

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Tuesday, July 23, 2013

How To Start Your Own Online Business With Affiliate Marketing ...

Are you looking to learn how to start your own online business? Then you are on the right page, because in this article we will quickly go over how to get an online business up and running.

It is actually quite easy to go about starting an online business in the modern internet era and the initial investment is very low compared to the offline world. If you were to buy an offline business then it would likely cost you thousands and a bank loan may even be required. Not to mention it is unlikely that your new business will see a profit until a matter of months or even years.

But when you start your own online business then all you need is some essential marketing tools and a basic education and you can be up and running and making money potentially within days.

So let?s look at how to start your business on the internet. First of all you need to determine what product or service you will be providing to the marketplace and you need to decide what your target audience is.

For me, I think it is an excellent idea to start out with affiliate marketing when first looking to make money online. Because with affiliate marketing you do not need your own products or services to sell and as a result you don?t need to deal with customer support issues and more complicated parts of business. As an affiliate you simply promote other peoples products an earn a commission when sales are made.

It is quite a newbie friendly way to start earning money with an online business and requires minimal investment. The main skill needed to succeed with affiliate marketing is the ability to drive traffic to an affiliate offer. When you are able to do this on a consistent basis then you can somewhat automate your marketing and earn a healthy residual income each month without having to invest much time into daily work.

The best way to get started with an online business as an affiliate marketer would be to get hold of a turnkey marketing system that takes care of the technical setup for you, as well as provides you with a whole suite of products to promote in return for commissions.

That way all you need to do is do marketing on the internet in the form of solo ads, videos, articles, blog posts and banner ads etc. and drive traffic into the system. The sales funnel that is already in place will then take care of the rest for you.

????????

Would you like to discover the best type of sales funnel to ?plug-in? to in order to fast track your online business success? Then visit http://WebTrafficToolkit.com/


Source: http://www.advsecret.com/how-to-start-your-own-online-business-with-affiliate-marketing/

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Woman breaks into fire station, smashes windows with axe

SPOKANE, Wash. -

A woman broke into a fire station, stole an axe, and started busting windows with it in north Spokane this morning. It all happened around 3:30 a.m. at Fire Station 3 near Ash and Indiana.

Police say they were called to the scene from reports of a woman running around in the street. Officers say she already busted out a car window at the D.O.C. building nearby, and was making her way to Fire Station 3.

"It appears one of the doors was left unlocked and that's how she made entry into there and then was able to get the axe from inside," Lt. Rex Olson with the Spokane Police Department said.

Officers say the woman, identified as 27-year-old Lillian Sowa, then started breaking windows in the front of the station. Investigators believe she was intoxicated, but don't know what she was using.

"It resulted in her losing her mental stability and going off and doing these types of crazy things," Lt. Olson said.

When SPD arrived, Sowa wouldn't put down the axe and even started walking towards the officers with it lifted next to her head.

"She was apparently so delusional that she did not believe they were real police officers, even though they were in full uniform and they had marked cars, and would not comply with what they were saying to her," Lt. Olson added.

She was then tased by officers.

Lislie Welch Junior lives across the street an woke up to the woman screaming for help.

"It was just the sound of her voice, she was having a bad time," he said.

Now Welch says it may have been the woman getting taken down by officers.

In the 40 years he's lived on the north Spokane street, he says nothing surprises him anymore. But this incident did.

"(The station) is a place where you go for help, not where you go to do a bunch of vandalism," Welch said.

Lillian Sowa was booked into jail Sunday morning. She faces charges of first degree burglary, second degree assault for coming at an officer with deadly weapon, and malicious mischief.

Source: http://www.kxly.com/news/spokane-news/woman-breaks-into-fire-station-smashes-windows-with-axe/-/101214/21092662/-/99a0dn/-/index.html

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Monday, July 22, 2013

Apple's maps strategy is working just fine

Sorry, Readability was unable to parse this page for content.

Source: http://www.facebook.com/permalink.php?story_fbid=612485878785024&id=115705605129723

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Billy Ray and Tish Cyrus Call Off Divorce, Get Back Together After Couples Therapy!

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Scientists to study novel mechanisms of epileptic seizures to identify targets for therapy

Scientists to study novel mechanisms of epileptic seizures to identify targets for therapy [ Back to EurekAlert! ] Public release date: 22-Jul-2013
[ | E-mail | Share Share ]

Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside

Competitive $1.7 million grant from National Institutes of Health to UC Riverside will support investigation of hyperexcitability in the brain

RIVERSIDE, Calif. Ten percent of Americans experience a seizure in their lifetime, with three million diagnosed with epilepsy, a chronic neurological disorder. Anticonvulsant medications can mitigate the hyperactivity of neurons that leads to seizures, but not without severe side effects, including cognitive impairment.

Now, researchers Todd Fiacco, Ph.D., and Devin Binder, M.D., Ph.D., at the University of California, Riverside will spend the next five years studying the causes of neuronal hyperexcitability with the goal of developing more effective treatments for brain disorders like epilepsy. The researchers will share a National Institutes of Health (NIH) grant totaling more than $1.7 million awarded to them as co-principal investigators of the project.

Besides improving our understanding of how brain cells communicate with each other, the research has the potential to lead to treatments for brain disorders and diseases such as epilepsy, stroke and Alzheimer's disease.

"We're very excited about the opportunity to work together on this project," said Binder, a clinician and an associate professor of biomedical sciences in the School of Medicine. "We've collaborated over the past two years, generating a lot of supporting data for this research."

As a neurosurgeon, Binder has worked with a number of epilepsy patients, an experience that led him to study animal models of seizures in his lab at UC Riverside.

"The patients I've worked with suffer terrible side effects from antiepileptic drugs," he said. "Without new treatments, impaired cognition is the trade-off for preventing severe seizures."

Part of the problem is how researchers have traditionally thought of disorders like epilepsy. Aside from triggering seizures, the hyperactivity of neurons can lead to cell death; as a result, anticonvulsants are prescribed to reduce neuronal activity across the brain, which leads to side effects. The cause of the neuronal hyperexcitability is still unknown, but Fiacco and Binder are gathering evidence to suggest that it may involve expansive star-shaped glial cells found in the brain called astrocytes.

"A single astrocyte surrounds many thousands of synapses in the brain," said Fiacco, an assistant professor of cell biology and neuroscience. "By manipulating astrocytes, you have another tool for controlling neuronal activity."

This is exactly what Fiacco has been doing since arriving at UCR in 2008. In his lab, he exploits a process called "astrocytic swelling" to manipulate astrocytes.

Fiacco explained that in order to maintain a balanced osmolarity, astrocytes take up water via channels unique to them called aquaporin 4. This can lead to selective swelling of astrocytes during bouts of elevated neuronal activity. One result of this swelling is the release of neurotransmitters like glutamate through volume-regulated anion channels (VRACs) that are critical for cell volume regulation. Glutamate, being the most common excitatory neurotransmitter in the brain, will then bind to receptors on neurons and elevate neuronal activity. Being able to selectively manipulate astrocytes while recording neuronal activity is a key challenge in the NIH-funded project.

"Astrocytic swelling could be a novel target for antiepileptic treatment," Binder said. "Hypertonic saline treatment will shrink astrocytes and could be a quick and specific method for preventing massive seizure activity. Pharmacological agents could also be used to block VRACs from releasing glutamate. Thanks to Dr. Fiacco's work, we can quantify the effects of these treatments on isolated brain tissue in vitro."

In vitro work is critical for establishing grounds to test these treatments in vivo with live animals. That's where Binder's lab comes in. His work with mouse models of epilepsy will allow him to test the effects of manipulating astrocytic swelling on seizure thresholds.

"We also plan to measure astrocytic swelling before and during a seizure in vivo with modern imaging techniques like two-photon microscopy," he said. "That's where the strength of this project lies: being able to study the relationship of astrocytic swelling on neuronal excitability not only at the behavioral level in vivo, but also at the cellular level in vitro."

Both Binder and Fiacco agree that this collaboration never could have happened without UCR's Center for Glial Neuronal Interactions (CGNI), of which they are members.

"It's the center's monthly meetings that fostered our collaboration," Fiacco said.

Fiacco and Binder will be assisted by graduate students and laboratory technicians in the research project. Results will be presented at various venues including CGNI meetings, the annual CGNI research symposium at UCR, and national and international research conferences.

###

By Philip Vieira

The University of California, Riverside (http://www.ucr.edu) is a doctoral research university, a living laboratory for groundbreaking exploration of issues critical to Inland Southern California, the state and communities around the world. Reflecting California's diverse culture, UCR's enrollment has exceeded 21,000 students. The campus will open a medical school in 2013 and has reached the heart of the Coachella Valley by way of the UCR Palm Desert Center. The campus has an annual statewide economic impact of more than $1 billion. A broadcast studio with fiber cable to the AT&T Hollywood hub is available for live or taped interviews. UCR also has ISDN for radio interviews. To learn more, call (951) UCR-NEWS.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Scientists to study novel mechanisms of epileptic seizures to identify targets for therapy [ Back to EurekAlert! ] Public release date: 22-Jul-2013
[ | E-mail | Share Share ]

Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside

Competitive $1.7 million grant from National Institutes of Health to UC Riverside will support investigation of hyperexcitability in the brain

RIVERSIDE, Calif. Ten percent of Americans experience a seizure in their lifetime, with three million diagnosed with epilepsy, a chronic neurological disorder. Anticonvulsant medications can mitigate the hyperactivity of neurons that leads to seizures, but not without severe side effects, including cognitive impairment.

Now, researchers Todd Fiacco, Ph.D., and Devin Binder, M.D., Ph.D., at the University of California, Riverside will spend the next five years studying the causes of neuronal hyperexcitability with the goal of developing more effective treatments for brain disorders like epilepsy. The researchers will share a National Institutes of Health (NIH) grant totaling more than $1.7 million awarded to them as co-principal investigators of the project.

Besides improving our understanding of how brain cells communicate with each other, the research has the potential to lead to treatments for brain disorders and diseases such as epilepsy, stroke and Alzheimer's disease.

"We're very excited about the opportunity to work together on this project," said Binder, a clinician and an associate professor of biomedical sciences in the School of Medicine. "We've collaborated over the past two years, generating a lot of supporting data for this research."

As a neurosurgeon, Binder has worked with a number of epilepsy patients, an experience that led him to study animal models of seizures in his lab at UC Riverside.

"The patients I've worked with suffer terrible side effects from antiepileptic drugs," he said. "Without new treatments, impaired cognition is the trade-off for preventing severe seizures."

Part of the problem is how researchers have traditionally thought of disorders like epilepsy. Aside from triggering seizures, the hyperactivity of neurons can lead to cell death; as a result, anticonvulsants are prescribed to reduce neuronal activity across the brain, which leads to side effects. The cause of the neuronal hyperexcitability is still unknown, but Fiacco and Binder are gathering evidence to suggest that it may involve expansive star-shaped glial cells found in the brain called astrocytes.

"A single astrocyte surrounds many thousands of synapses in the brain," said Fiacco, an assistant professor of cell biology and neuroscience. "By manipulating astrocytes, you have another tool for controlling neuronal activity."

This is exactly what Fiacco has been doing since arriving at UCR in 2008. In his lab, he exploits a process called "astrocytic swelling" to manipulate astrocytes.

Fiacco explained that in order to maintain a balanced osmolarity, astrocytes take up water via channels unique to them called aquaporin 4. This can lead to selective swelling of astrocytes during bouts of elevated neuronal activity. One result of this swelling is the release of neurotransmitters like glutamate through volume-regulated anion channels (VRACs) that are critical for cell volume regulation. Glutamate, being the most common excitatory neurotransmitter in the brain, will then bind to receptors on neurons and elevate neuronal activity. Being able to selectively manipulate astrocytes while recording neuronal activity is a key challenge in the NIH-funded project.

"Astrocytic swelling could be a novel target for antiepileptic treatment," Binder said. "Hypertonic saline treatment will shrink astrocytes and could be a quick and specific method for preventing massive seizure activity. Pharmacological agents could also be used to block VRACs from releasing glutamate. Thanks to Dr. Fiacco's work, we can quantify the effects of these treatments on isolated brain tissue in vitro."

In vitro work is critical for establishing grounds to test these treatments in vivo with live animals. That's where Binder's lab comes in. His work with mouse models of epilepsy will allow him to test the effects of manipulating astrocytic swelling on seizure thresholds.

"We also plan to measure astrocytic swelling before and during a seizure in vivo with modern imaging techniques like two-photon microscopy," he said. "That's where the strength of this project lies: being able to study the relationship of astrocytic swelling on neuronal excitability not only at the behavioral level in vivo, but also at the cellular level in vitro."

Both Binder and Fiacco agree that this collaboration never could have happened without UCR's Center for Glial Neuronal Interactions (CGNI), of which they are members.

"It's the center's monthly meetings that fostered our collaboration," Fiacco said.

Fiacco and Binder will be assisted by graduate students and laboratory technicians in the research project. Results will be presented at various venues including CGNI meetings, the annual CGNI research symposium at UCR, and national and international research conferences.

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By Philip Vieira

The University of California, Riverside (http://www.ucr.edu) is a doctoral research university, a living laboratory for groundbreaking exploration of issues critical to Inland Southern California, the state and communities around the world. Reflecting California's diverse culture, UCR's enrollment has exceeded 21,000 students. The campus will open a medical school in 2013 and has reached the heart of the Coachella Valley by way of the UCR Palm Desert Center. The campus has an annual statewide economic impact of more than $1 billion. A broadcast studio with fiber cable to the AT&T Hollywood hub is available for live or taped interviews. UCR also has ISDN for radio interviews. To learn more, call (951) UCR-NEWS.


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Source: http://www.eurekalert.org/pub_releases/2013-07/uoc--sts072213.php

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